Clinical Trials Currently Enrolling At Rhode Island Hospital For Patients With Pulmonary Arterial Hypertension

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Primary Arterial Hypertension

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CLINICAL TRIALS CURRENTLY ENROLLING AT RHODE ISLAND HOSPITAL FOR PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION
8/25/2005

CLINICAL TRIAL	DATE ENROLL ENDS
ARIES –1 Ambrisentan in PAH- A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Study of Ambrisentan in Subjects with Pulmonary Arterial Hypertension	Start 9/03 Ends – when MYOGEN, INC reaches desired enrollment numbers
ARIES-EX – An extension to the ARIES –1 study for subjects who are benefiting from Ambrisentan	Same as ARIES -1
Pfizer A148-1141 A Multicenter, multinational, randomized, double-blind, placebo controlled, parallel group study to assess the safety and efficacy of a subject optimized dose of Sildenafil (20, 40, and 80mg Sildenafil) TID based on toleration, when used in combination with intravenous Prostacyclin (Epoprostenol, Flolan) in the treatment of pulmonary arterial hypertension	Start 2003- When Pfizer reaches desired enrollment numbers
3. Pfizer Extension study A148-1153 Subjects allowed to roll over into Extension study if showing improvement with medication.	Same as Pfizer A148-1141
INOT32c—INO Therapeutics sponsor Dose Response of Pulsed Nitric Oxide in Adults with COPD Requiring Long-Term Oxygen Therapy	Starting September 19,2005
INOT33—Extension study to INOT32c	Same as above,
REVEAL – Sponsor United Therapeutics Study for site pain, for subjects using Remodulin sub-cutaneously	Start 6/24/04 Ends when desired enrollment is reached.
AMB 222—Sponsor Myogen, Inc Study for subjects who have failed treatment with Bosentan due to elevated LFT’s	Start 4/2005 Ends: When sponsor reaches desired enrollment
Flolan to Remodulin Transition Study Sponsor: Dr. Nicholas HillNew Eng Med Center Hosp, Boston, MA	Start 6/03 Ends When sponsor, Dr. Nicholas Hill reaches desired enrollment
Flolan to Tracleer Sponsor: Dr. Nicholas Hill New Eng Med Center Hospital, Boston, MA	Start 6/03 Ends when sponsor reaches desired enrollment
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of the Phosphodiesterase Type 5 (PDE5) Inhibitor Tadalafil (Cialis) in the Treatment of patients with Pulmonary Arterial Hypertension	Start: Oct-Nov/2005 Stop Nov/2006
Extension study for Tadalafil (Cialis)	Start Oct-Nov /2005 Stop: ongoing X 2 years
Iloprost in post-operative cardiothoracic patients who have pulmonary hypertension	Start Oct-Nov/2005 Stop Nov /2006

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Have you or a loved one been diagnosed or have:

Pulmonary Hypertension?			Yes No
Primary Pulmonary Hypertension (PPH)?			Yes No
Pulmonary Arterial Hypertension (PAH)?			Yes No
Persistent Pulmonary Hypertension Newborn?			Yes No
Have you had a Valve Replacement?			Yes No
Are you on a treatment such as Flolan, Tracleer, Remodulin, Rivatio (Viagra), Ventavis, or other?			Yes No
Did you or your loved one take Fen Phen or other Diet Drugs?			Yes No
Did Mom take any antidepressant while pregnant resulting in a child with a diagnosis of Persistent Pulmonary Hypertension Newborn?			Yes No

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